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CDHB

Benzodiazepines

• Rarely serious in isolation but may need prolonged observation.
• Management is supportive (especially of airway and breathing).
• Flumazenil is a direct antidote but is rarely required.

Note: t½ flumazenil is one hour, i.e., sedation can recur as t½ of benzodiazepines is usually longer.

Note: Do not use flumazenil in mixed overdoses (e.g., benzodiazepines and tricyclic antidepressants). It may precipitate toxic seizures.

Topic Code: 1586